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ChroNOline ™

August 19, 2020

ChroNOline™ - the benefits and uses

Also known as an ‘anti-wrinkle peptide’, ChroNOline is an ingredient that has been proven to reduce the appearance of fine lines and wrinkles. In one clinical trial, which involved 27 women aged between 40 and 65, it reduced fine lines and wrinkles by 29% over 28 days.

ChroNOline is a great addition to your skincare routine if you’re looking to maintain a smooth, firm and wrinkle-free complexion. In this glossary, you’ll learn all about ChroNOline, including what it is, the main benefits, relevant Facetheory products and how to add it to your routine. 

What is ChroNOline?

ChroNOline is a biomimetic lipopeptide also known as caproyl tetrapeptide-3, comprising four amino acids linked to a lipid (caproic acid). It is derived from a growth factor known as TGF-ß.

In-vitro testing has demonstrated that ChroNOline stimulates the production of laminin, fibronectin and collagen VII – vital components of the dermo-epidermal junction (DEJ). Laminin-5 is a glycoprotein that anchors the epidermis to the dermis.

By protecting and restoring the cell-matrix interactions associated with cellular turnover and regeneration, ChroNOline encourages skin’s natural repair processes and minimises the visible signs of ageing, including fine lines and wrinkles. ChroNOlineis also used to treat stretch marks and acne scars.

In short, it boosts the production of key components that help with skin structure support. As a result, your skin will be smoother and stronger. ChroNOline targets the skin’s elasticity, so it can bounce back and give you a youthful, healthy appearance. 

Benefits of ChroNOline in skincare products

1. Significant and sustained reduction of fine lines and wrinkles

ChroNOline is shown to increase production of collagen-3 by 34 percent, laminin by 26 percent and laminin-5 by 49 percent. By stimulating laminin and fibronectin production, ChroNOline helps to promote optimal cell function and maintain the integrity of the dermo-epidermal junction. In a clinical trial, ChroNOline reduced fine lines and wrinkles by as much as 29 percent after 28 days.

2. Reduced appearance of stretch marks

When applied to the body, ChroNOline was shown to reduce the appearance of stretch marks, improve skin tone and promote smoothness and elasticity. Subjects in a recent study noted visible results after just 4... Read More

ChroNOline™ - the benefits and uses

Also known as an ‘anti-wrinkle peptide’, ChroNOline is an ingredient that has been proven to reduce the appearance of fine lines and wrinkles. In one clinical trial, which involved 27 women aged between 40 and 65, it reduced fine lines and wrinkles... Read More

ChroNOline™ - the benefits and uses

Also known as an ‘anti-wrinkle peptide’, ChroNOline is an ingredient that has been proven to reduce the appearance of fine lines and wrinkles. In one clinical trial, which involved 27 women aged between 40 and 65, it reduced fine lines and wrinkles by 29% over 28 days.

ChroNOline is a great addition to your skincare routine if you’re looking to maintain a smooth, firm and wrinkle-free complexion. In this glossary, you’ll learn all about ChroNOline, including what it is, the main benefits, relevant Facetheory products and how to add it to your routine. 

What is ChroNOline?

ChroNOline is a biomimetic lipopeptide also known as caproyl tetrapeptide-3, comprising four amino acids linked to a lipid (caproic acid). It is derived from a growth factor known as TGF-ß.

In-vitro testing has demonstrated that ChroNOline stimulates the production of laminin, fibronectin and collagen VII – vital components of the dermo-epidermal junction (DEJ). Laminin-5 is a glycoprotein that anchors the epidermis to the dermis.

By protecting and restoring the cell-matrix interactions associated with cellular turnover and regeneration, ChroNOline encourages skin’s natural repair processes and minimises the visible signs of ageing, including fine lines and wrinkles. ChroNOlineis also used to treat stretch marks and acne scars.

In short, it boosts the production of key components that help with skin structure support. As a result, your skin will be smoother and stronger. ChroNOline targets the skin’s elasticity, so it can bounce back and give you a youthful, healthy appearance. 

Benefits of ChroNOline in skincare products

1. Significant and sustained reduction of fine lines and wrinkles

ChroNOline is shown to increase production of collagen-3 by 34 percent, laminin by 26 percent and laminin-5 by 49 percent. By stimulating laminin and fibronectin production, ChroNOline helps to promote optimal cell function and maintain the integrity of the dermo-epidermal junction. In a clinical trial, ChroNOline reduced fine lines and wrinkles by as much as 29 percent after 28 days.

2. Reduced appearance of stretch marks

When applied to the body, ChroNOline was shown to reduce the appearance of stretch marks, improve skin tone and promote smoothness and elasticity. Subjects in a recent study noted visible results after just 4 weeks. After 8 weeks, 68 percent of subjects reported that their stretch marks appeared less dilated and diffused.

3. Smoothing and toning skin

In the same study, the majority of subjects observed that their skin was suppler, smoother and more elastic after 4 weeks of regular application. They also noted a significantly improved skin tone and texture.

4. Firmer skin

When we age, we see a decrease in epidermal thickness. The dermoepidermal junction also flattens, which interferes with the skin’s natural repair process. This loss in elasticity and support leads to more wrinkles. By using ChroNOline, you can restore some of this loss in elasticity, resulting in firmer and smoother skin. 

How to use ChroNOline

ChroNOline is found in a variety of skincare products, rather than being applied directly to the skin. For example, it’s found in some anti-ageing creams and serums. 

It’s recommended to use ChroNOline twice daily morning and evening. You can apply it to the whole face, or specific areas like the skin around your eyes and lips. 

When to use ChroNOline

ChroNOline can be used as a preventative measure for people over the age of 25. It can also be used by people who want to reduce the appearance of wrinkles, fine lines and crow’s feet. In a clinical study, participants saw a 29% reduction in wrinkles and fine lines in 28 days, but it’s best to start using this ingredient at the earliest opportunity for long-term results. 

ChroNOline skincare products from Facetheory

Our PolyPep Collagen Boosting Serum S8 is formulated with 2.5% ChroNOline. It’s retinol free, too, so it’s perfect for sensitive skin. Apply a few drops to clean, damp skin and then follow up with a moisturiser of your choice. 

 

Frequently Asked Questions

Is ChroNOline suitable for my skin type? 

ChroNOline is recommended for all skin types, especially mature or sensitive skin types. It is gentle enough to use on the delicate skin in the eye area.

Can ChroNOline be used alongside other products?

ChroNOline works well in combination with other products. It is safe for use alongside other key actives such as polyhydroxy acids.

How often should I apply ChroNOline?

ChroNOline can be used twice a day. Apply a product containing ChroNOline to thoroughly cleansed skin in the morning and at night.

What is the recommended dosage of chronoline?

  • Intensive treatment: 2.5%
  • Preventive treatment: 1% to 2.5%
  • Skin repair treatment / dermocosmeticals: 0.3% to 1%